Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies
نویسندگان
چکیده
منابع مشابه
The retinoblastoma tumor suppressor and stem cell biology.
Stem cells play a critical role during embryonic development and in the maintenance of homeostasis in adult individuals. A better understanding of stem cell biology, including embryonic and adult stem cells, will allow the scientific community to better comprehend a number of pathologies and possibly design novel approaches to treat patients with a variety of diseases. The retinoblastoma tumor ...
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Size control is essential for all proliferating cells, and is thought to be regulated by checkpoints that couple cell size to cell cycle progression. The aberrant cell-size phenotypes caused by mutations in the retinoblastoma (RB) tumor suppressor pathway are consistent with a role in size checkpoint control, but indirect effects on size caused by altered cell cycle kinetics are difficult to ru...
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Notch signaling regulates a broad spectrumof cell fate decisions and differentiation. Both oncogenic and tumor suppressor functions have been shown for Notch signaling. However, little is known about the underlying mechanisms of its tumor suppressor function. Here, we report that expression of Notch3, a member of Notch family transmembrane receptors, was elevated in human cells during senescenc...
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متن کاملCancer stem cell characteristics in retinoblastoma.
PURPOSE There is increasing evidence that cancer stem cells contribute to tumor progression and chemoresistance in a variety of malignancies, including brain tumors, leukemias, and breast carcinomas. In this study, we tested the hypothesis that retinoblastomas contain subpopulations of cells that exhibit cancer stem cell properties. METHODS The following sources of retinoblastoma cells and ti...
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ژورنال
عنوان ژورنال: World Journal of Stem Cells
سال: 2016
ISSN: 1948-0210
DOI: 10.4252/wjsc.v8.i4.170